Influence of the adrenal glands on DNA synthesis in normal and compensating kidneys

✍ Scribed by Reiter, Russel J. ;McCreight, Charles E.

• Publisher: John Wiley and Sons
• Year: 1965
• Tongue: English
• Weight: 416 KB
• Volume: 160
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1401600110

✦ Synopsis

The role of the adrenal glands in controlling the synthesis of deoxyribonucleic acid in normal and compensating kidneys of rats given saline drinking fluid was studied using tritiated-thymidine and radioautography. Adrenalectomy alone increased significantly the labeling indices of the renal cortex and medulla of otherwise intact rats.

Two days following unilatral nephrectomy of rats with intact adrenal glands, the number of labeled nuclei in the remaining kidney increased by factors of about 4 and 2.5 in the cortex and the medulla, respectively. Adrenalectomy moderately