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Influence of surgery on the responsiveness of blood lymphocytes in patients with advanced cancer

✍ Scribed by I. Grzelak; W. L. Olszewski; A. Engeset

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
674 KB
Volume
37
Category
Article
ISSN
0022-4790

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✦ Synopsis

The effect of surgery on peripheral blood mononuclear cell responsiveness to mitogens and supressor cell (SC) activity assessed in a concanavalin A (ConA) assay were studied in patients with stage 0 and stage HI-IV cancer. Patients were exposed to a similar surgical trauma the same type of anaesthesia, and to no pre-and early postoperative radio-or chemotherapy. A more pronounced postoperative decrease in the lymphocyte count, responsiveness to phytohemagglutinin (PHA) and ConA, and in the SC activity was found in the nonadvanced than advanced cancer group. These findings point to an impaired mobilization and distribution capacity of circulating lymphocytes in patients with advanced neoplastic disease.

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