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Influence of substituents on enantiomeric ratio in transesterification of racemic C-3 synthons using lipase B from Candida antarctica

✍ Scribed by Bård Helge Hoff; Liv Ljones; Anja Rønstad; Thorleif Anthonsen


Book ID
114396494
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
166 KB
Volume
8
Category
Article
ISSN
1381-1177

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Lipase-catalysed hydrolysis of butanoates of 3-methoxy-1-(phenylmethoxy)-2-propanol and 3-chloro-l-(phenylmethoxy)-2-propanol with various lipases gave low enantioselectivity, E. By additon of water miscible organic cosolvents, in particular tert-butanol and acetone, the E-value was raised from 7 to