Influence of site-directed mutagenesis on protein assembly and solubility of tadpole H-chain ferritin

Structural insights into Alzheimer filam

Structural insights into Alzheimer filament assembly pathways based on site-directed mutagenesis and S-glutathionylation of three-repeat neuronal Tau protein

✍ Luca Dinoto; Michael A. Deture; Daniel L. Purich 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 420 KB

## Abstract Although Tau and MAP2 readily assemble into straight filaments (SFs), Tau's unique ability to form paired‐helical filaments (PHFs) may offer clues as to why Tau's microtubule‐binding region (MTBR) is the exclusive building block of the neurofibrillary tangles that accumulate during Alzh