Influence of reductive carboxylation on redox state of cancer cells
✍ Scribed by Dvorak⁎, A.; Zelenka, J.; Smolkova, K.; Vitek, L.; Jezek, P.
- Book ID
- 122935172
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 31 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0891-5849
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A reduction of the external redox potential from 343 mV (atmospheric 02 saturation) to 143 mV had only a slight effect on heavy metal uptake by whole cells of Chlorella fusca but caused an increased copper adsorption and a threefold increase of lead accumulation by isolated cell walls.
The redox state has been shown to regulate a variety of biochemical functions including cellular proliferation. Previous studies from our laboratory and others have shown that the binding of many transcription factors to their cognate DNA sequences is sensitive to the redox environment. Therefore, i