Influence of recombinant human interleukin (IL)-7 on disease progression in mice infected with friend virus complex
✍ Scribed by Li Lu; Zhen Zhou; Bo Wu; Mang Xiao; Rong-Nian Shen; Douglas E. Williams; Young-Junc Kim; Byoung S. Kwon; Sandra Ruscetti; Hal E. Broxmeyer
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 821 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Recombinant human (rhu) IL-7 was evaluated for its influence on disease progression in mice infected with the polycythemiainducing strain of the Friend virus complex (FVC). D B A I I mice were injected i.v. with FVC, and then treated S.C. with rhulL-7. IL-7 significantly prolonged survival time and decreased spleen focus-forming virus (SFFV) levels, expression of SFFV mRNA and SFFV protein production in FVC-infected mice. IL-7 did not appear to directly inactivate SFFV. Although both splenic weight and cellularity in FVC-infected mice treated with IL-7 were higher than those of normal mice, they were respectively 58% and 66% lower than those of the untreated FVC-infected mice. NK-cell activity was substantially lower in FVC-infected mice than in normal mice, while IL-7 restored NK-cell activity to normal levels. IL-6 and IFN-y levels were markedly reduced in FVC-infected mice compared to normal mice, but treatment of FVC-infected mice with IL-7 restored these cytokine levels. While the actual mechanisms of these effects are not yet known, the results suggest the potential therapeutic efficacy of IL-7 for certain hematopoietic and viral disorders, possibly mediated through an action on accessory cells and cytokine production.