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Influence of protein binding and lipophilicity on the distribution of chemical compounds in in vitro systems

✍ Scribed by M. Gülden; H. Seibert

Book ID
117587860
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
503 KB
Volume
11
Category
Article
ISSN
0887-2333

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## Abstract For a correct determination of acrolein amounts generated in in vitro turnover experiments with oxazaphosphorines, it is necessary to characterize the interaction of acrolein with liver microsomal proteins. Acrolein, a highly reactive metabolite of oxazaphosphorines, readily forms coval