Influence of proline-14 substitution on the secondary structure in a synthetic analogue of alamethicin

Influence of the secondary structure on

Influence of the secondary structure on the pore forming properties of synthetic alamethicin analogs: NMR and molecular modelling studies

✍ Laurent Brachais; Catherine Mayer; Daniel Davoust; Gérard Molle 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 982 KB

Synthetic alamethicin analogs, in which all Aib residues had been replaced by Leu (L2) then proline 14 replaced by an alanine (L5), were studied in SDS micelles using circular dichroism and NMR spectroscopy. Nuclear Overhauser effects were used as constraints for molecular modelling. The structures