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Influence of pre-hydration and pharmacogenetics on plasma methotrexate concentration and renal dysfunction following high-dose methotrexate therapy

โœ Scribed by Yanagimachi, Masakatsu; Goto, Hiroaki; Kaneko, Tetsuji; Naruto, Takuya; Sasaki, Koji; Takeuchi, Masanobu; Tanoshima, Reo; Kato, Hiromi; Yokosuka, Tomoko; Kajiwara, Ryosuke; Fujii, Hisaki; Tanaka, Fumiko; Goto, Shoko; Takahashi, Hiroyuki; Mori, Masaaki; Kai, Sumio; Yokota, Shumpei

Book ID
121593936
Publisher
Carden Jennings Publishing
Year
2013
Tongue
English
Weight
178 KB
Volume
98
Category
Article
ISSN
0925-5710

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โœ Hempel, Lutz ;Misselwitz, Joachim ;Fleck, Christian ;Kentouche, Karim ;Leder, Ch ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 174 KB

## Abstract ## Background The present investigation was intended to further clarify the mechanisms involved in renal dysfunction following highโ€dose methotrexate (HDโ€MTX) treatment. ## Patients and Methods Fifty eight predominately pediatric patients [39 male, 19 female; mean age 12.3 years (ran