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Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: simulation of the food effect

โœ Scribed by Modi, Marlene Woodruff; Hassett, James M; Lalka, David

Book ID
109844362
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
619 KB
Volume
44
Category
Article
ISSN
0009-9236

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A computer simulation of the food effect: Transient changes in hepatic blood flow and michaelis-menten parameters as mediators of hepatic first pass metabolism and bioavailability of propranolol
โœ H. A. Semple; Dr. Y. K. Tam; R. T. Coutts ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 744 KB

A physiological model of propranolol disposition was designed to help explain the large increase in AUC seen when the drug is administered with food. The mass balance equation for the liver compartment used Michaelis-Menten terms to describe hepatic metabolism. Previously published pharmacokinetic a