Influence of polymorphisms for apolipoprotein B (ins/del, Xbal, EcoRI)and apolipoprotein E on serum lipids and apolipoproteins in a Javanese population

✍ Scribed by B. Gajra; J. K. Candlish; N. Saha; C. K. Heng; A. G. Soemantri; J. S. H. Tay

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 500 KB
• Volume: 11
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370110103

✦ Synopsis

A total of 231 healthy subjects from a central Javanese population were investigated for the distribution of three apolipoprotein B (apo B) polymorphisms (insidel, XbuI, and EcoRI), as well as apolipoprotein E (apo E) polymorphism in relation to serum lipid and apolipoprotein concentrations. The frequencies of the rarer alleles (del, 0.09; X + , 0.1; and R -, 0.06) were lower than have been found for some Asian and European populations. Distribution of genotypes was in Hardy-Weinburg equilibrium for all the polymorphisms. A linkage disequilibrium was observed only between the insldel and XbaI site polymorphisms of apo B (x4* = 25.3; P < 0.001) consistent with that observed in some other population studies.

No polymorphism of the apo B gene had an association with serum lipid or apolipoprotein concentrations in this population except for XubI, which appeared to be associated with serum TG (as the log transform: R2 = 8.3; F = 4.8; P < 0.01). The apo E4 allele was found to be associated with significantly higher serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC). Apo E polymorphism explained 5.9% of the sample variance of serum LDLC (F = 5.4; P < 0.01).