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Influence of Polymorphism on the Surface Energetics of Salmeterol Xinafoate Crystallized from Supercritical Fluids

โœ Scribed by Henry H. Y. Tong; Boris Yu. Shekunov; Peter York; Albert H. L. Chow

Book ID
110336185
Publisher
Springer US
Year
2002
Tongue
English
Weight
225 KB
Volume
19
Category
Article
ISSN
0724-8741

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Influence of operating temperature and p
Influence of operating temperature and pressure on the polymorphic transition of salmeterol xinafoate in supercritical fluids
โœ Henry H. Y. Tong; Boris Y. Shekunov; Peter York; Albert H. L. Chow ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 101 KB

Precipitation of pure polymorphic forms (I and II) of salmeterol xinafoate (SX) in supercritical fluids was investigated as a function of operating pressure and temperature. It has been shown that the formation of each polymorph is governed by both thermodynamic shift and kinetic effects, which are