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Influence of Plasma-protein Binding on Analgesic Effect of Methadone in Rats with Spontaneous Withdrawal

โœ Scribed by M. J. GARRIDO; R. JIMINEZ; E. GOMEZ; R. CALVO

Book ID
118110224
Publisher
Pharmaceutical Press
Year
1996
Tongue
English
Weight
403 KB
Volume
48
Category
Article
ISSN
2042-7158

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Methadone is a basic drug highly bound to a1-acid glycoprotein (AGP), a plasma protein that increases in several pathological situations. Our aims were to evaluate the processes (pharmacokinetics-PK and/or pharmacodynamics-PD) associated with changes of methadone analgesia under conditions of increa