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Influence of pH on the interaction of inhibitors with triosephosphate isomerase and determination of the pKa of the active-site carboxyl group

✍ Scribed by Hartman, Fred C.; LaMuraglia, Glen M.; Tomozawa, Yasuko; Wolfenden, Richard

Book ID
127070961
Publisher
American Chemical Society
Year
1975
Tongue
English
Weight
731 KB
Volume
14
Category
Article
ISSN
0006-2960

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## Abstract The key residue of the active site of triosephosphate isomerase (TIM) is the catalytic glutamate, which is proposed to be important (i) as a catalytic base, for initiating the reaction, as well as (ii) for the subsequent proton shuttling steps. The structural properties of this glutamat