Influence of perfusion flow rate on uptake and pharmacodynamics of quinidine in isolated perfused rat heart
β Scribed by Jiu Li Huang; Denis J. Morgan
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 534 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Intracellular [Na^+^], [H^+^], and [ATP] and mechanical performance were measured in the isovolumic perfused rat heart during ischemia. The concentration of intracellular sodium, [Na^+^]~i~, was determined by atomic absorption spectroscopy under control conditions, and [Na^+^] was monit
## Abstract The objective of this study was to determine the effects of repetitive ischemia on myocardial oxygen tension (pO~2~), consumption, and delivery in crystalloid normoperfused (perfuβsion pressure > 70 mmHg) and hypoperfused (perfusion pressure Λ50 mmHg) constant flow isolated rat hearts.
The present study describes an experimental setup that enables continuous measurement of cellular volumes in isolated organs. The procedure is a modification of a recently reported method that uses multinuclear NMR measured by 59Co NMR of cobalticyanide and 1H NMR of water in isolated rat hearts at
Two types of models have recently been proposed to describe hepatic uptake kinetics of protein bound drugs: a model in which dissociation from plasma protein is rate limiting the process, and a model in which an interaction between protein and hepatocyte surface is thought to promote dissociation an