Influence of nicotinic acid and pentaerythritoltetranicotinate (Perycit�, Bofors) on the cardiac output in man

✍ Scribed by Ekstr�m-Jodal, Barbro ;Harthon, Lennart ;H�ggendal, Egil ;Malmberg, Rolf ;Svedmyr, Nils

• Publisher: Springer-Verlag
• Year: 1970
• Weight: 385 KB
• Volume: 2
• Category: Article
• ISSN: 0369-9498
• DOI: 10.1007/bf00420712

✦ Synopsis

The effect of nicotinic acid and pentaerythritoltetranicotinate (Perycit®, Bofors) on cardiac output, FFA-level and content of free nicotinic acid in plasma was studied in healthy humans --. Nicotinic acid infused intravenously in a dose of 0.05 mg/kg/min for 180 rain or administered orally in a dose of 1 g increased the cardiac output maximally by about 20 per cent for 30--60 rain. The total peripheral resistance decreased and the pulse rate and stroke volume increased moderately.