The e&cts of newly synthesized cholesterol availability on bile acid synthesis are largely unknown, particularly in humans. The present study was aimed to study the changes induced on bile acid synthesis by simvastatin, a competitive inhibitor of hydroxymethyl glutaryl-CoA (HMG-CoA) reductase, the r
Influence of newly synthesized cholesterol on bile acid synthesis during chronic inhibition of bile acid absorption
β Scribed by Marco Bertolotti; Lisa Zambianchi; Lucia Carulli; Maria Sole Simonini; Marina Del Puppo; Marzia Galli Kienle; Paola Loria; Adriano Pinetti; Nicola Carulli
- Book ID
- 118686880
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 251 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0270-9139
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π SIMILAR VOLUMES
Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7a-hydroxylase, the rate-limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile ac
Bile acid synthesis is thought to be regulated by a negative feedback mechanism which is presumably dependent upon the flux of bile acids in the enterohepatic circulation. To characterize further the role of bile acids in regulation of bile acid synthesis, we have administered pure taurine or glycin