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Influence of Nanoparticles on the Brain-to-serum Distribution and the Metabolism of Valproic Acid in Mice

✍ Scribed by JOERG DARIUS; FRANK P. MEYER; BERNHARD A. SABEL; ULRIKE SCHROEDER


Book ID
111768545
Publisher
Pharmaceutical Press
Year
2000
Tongue
English
Weight
81 KB
Volume
52
Category
Article
ISSN
2042-7158

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Effect of multifactorial genetic liabili
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The present study shows that the multifactorial genetic liability to spontaneous exencephaly in the SELH/Bc mouse strain (10-20% of embryos) also confers an elevated risk of exencephaly induced by valproic acid. Treatment of pregnant dams (600 mg/kg sodium valproate in distilled water, i.p.) during