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Influence of N-terminal helix bundle stability on the lipid-binding properties of human apolipoprotein A-I

✍ Scribed by Masafumi Tanaka; Padmaja Dhanasekaran; David Nguyen; Margaret Nickel; Yuki Takechi; Sissel Lund-Katz; Michael C. Phillips; Hiroyuki Saito


Book ID
116273554
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
688 KB
Volume
1811
Category
Article
ISSN
1388-1981

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## Abstract Although the N‐terminal region in human apolipoprotein (apo) A‐I is thought to stabilize the lipid‐free structure of the protein, its role in lipid binding is unknown. Using synthetic fragment peptides, we examined the lipid‐binding properties of the first 43 residues (1–43) of apoA‐I i