Influence of Methotrexate Dose Intensity on Outcome of Patients with High Grade Osteogenic Osteosarcoma : Analysis of the literature

✍ Scribed by Stefan S. Bielack; Gerhard Beron; Kurt Winkler

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 62 KB
• Volume: 80
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19970801)80:3<516::aid-cncr22>3.0.co;2-z

✦ Synopsis

trating type. Survival of patients with MHC may de-

Influence of Methotrexate Dose

pend on the stage of the tumor.

Intensity on Outcome of Patients

Clinically, we need an exact preoperative diagnosis for surgical treatment. Examination of cytokeratin with High Grade Osteogenic expression in MHC is not beneficial preoperatively be-Osteosarcoma cause of the intermingling of the tumors. Therefore, we need more useful markers for MHC, e.g., a-fetoprotein, carcinoembryonic antigen, CA19-9, hypovas-Analysis of the Literature cularity, or a combination of these markers, as demonstrated in the previous report. 1 However, there have