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Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice

✍ Scribed by Xuefeng Han; Subat Turdi; Nan Hu; Rui Guo; Yingmei Zhang; Jun Ren

Book ID: 119304840
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 375 KB
Volume: 23
Category: Article
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2011.11.002

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## Abstract Caloric restriction (CR), which improves health and increases longevity, was studied as a therapy in a hexosaminidase β knockout mouse model of Sandhoff disease (SD), an incurable neurodegenerative disease involving accumulation of brain ganglioside GM2 and asialo‐GM2 (GA2). Adult mice