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Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein

✍ Scribed by Greg M. Cole; March D. Ard

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
180 KB
Volume
50
Category
Article
ISSN
1059-910X

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✦ Synopsis

Amyloid ␀-protein (A␀), the major component of plaques in Alzheimer's disease, is a small hydrophobic protein that is carried on apolipoprotein E (ApoE)-and ApoJ-containing lipoprotein particles in plasma and cerebrospinal fluid (CSF). Microglia, the scavenger cells of the CNS, take up and degrade A␀ via lipoprotein receptors including scavenger receptors A and B, and possibly via other receptors. Lipoproteins, ApoE, and ApoJ influence the uptake and degradation of A␀ in vitro and in vivo. Differences in ApoE-E4, -E3, and -E2 isoforms with respect to A␀ binding to lipoproteins and delivery to cells, including microglia, may contribute to the increased risk of Alzheimer's disease for people with an APOE4 genotype and to risk reduction with APOE2. Microsc.

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