Tight-binding inhibition by α-naphthofla
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Uhn Soo Cho; Eun Young Park; Mi Sook Dong; Bum Seok Park; Keehyuk Kim; Kyung Hyu
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Article
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2003
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Elsevier Science
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English
⚖ 429 KB
Human cytochrome P450 (P450) enzymes exhibit remarkable diversity in their substrate specificities, participating in oxidation reactions of a wide range of xenobiotic drugs. Previously, we reported that alpha-naphthoflavone (ANF) is bound to the recombinant P450 1A2 tightly and stabilizes an overall