INFLUENCE OF CIMETIDINE COADMINISTRATION
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R. A. Carr; F. M. Pasutto; R. T. Foster
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Article
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1996
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John Wiley and Sons
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English
β 834 KB
Sotalol (STL) is an amphoteric, chiral p-adrenergic blocking drug useful in the treatment of both hypertension and ventricular arrhythmias. In the human and rat, STL enantiomers are predominantly cleared from the body by the kidney as intact drug. The renal clearance (a,) of STL enantiomers substant