Influence of inorganic counterion on thermodynamic quantities of micellar solubilization of chiral pharmaceutical compounds in aqueous solutions of N-dodecoxycarbonylvaline using micellar electrokinetic chromatography

Determining thermodynamic quantities of

Determining thermodynamic quantities of micellar solubilization of chiral pharmaceutical compounds in aqueous solutions of N-dodecoxycarbonylvaline using micellar electrokinetic chromatography

✍ Alicia G. Peterson; Joe P. Foley 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 843 KB

Using the van't Hoff relationship, the enthalpy and entropy of transfer from the aqueous to a chiral micellar phase was measured for 12 pairs of enantiomeric pharmaceutical compounds, including p-agonists, p-blockers, and other p-amino alcohols. Selectivities, distribution coefficients, and Gibbs fr