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Influence of hyperbaric oxygenation on bilirubin and ditaurobilirubin auto-oxidation and porphyrin-sensitized photo-oxidation

✍ Scribed by M. Jirsa Jr.; M. Šíp; M. Jirsa

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 462 KB
Volume: 5
Category: Article
ISSN: 1011-1344
DOI: 10.1016/1011-1344(90)85045-x

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✦ Synopsis

Oxygen concentration controls the reaction rate of porphyrin-sensitized photo-oxidation under constant experimental conditions. The rate of bilirubin and ditaurobilirubin auto-oxidation and meso-tetra-(4-sulphonatophenyl) porphine-sensitized photo-oxidation in aqueous solution increases by about 3.5 times in 0.5 MPa of oxygen. Use of hyperbaric oxygenation in the photodynamic therapy of tumours and in the phototherapy of jaundice is proposed.

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