Influence of Glycerol-induced Acute Renal Failure on the Pharmacokinetics of Cyclosporin in Rats
β Scribed by NOBUHITO SHIBATA; TAKAHIRO OHMAE; NOBUO HOSHINO; TOKUZO MINOUCHI; AKIRA YAMAJI
- Book ID
- 111769780
- Publisher
- Pharmaceutical Press
- Year
- 1999
- Tongue
- English
- Weight
- 206 KB
- Volume
- 51
- Category
- Article
- ISSN
- 2042-7158
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Pharmacokinetic parameters of oltipraz were compared after intravenous and oral administration at a dose of 30 mg/kg to control rats and rats with U-ARF. After intravenous administration to rats with U-ARF, the AUC was significantly greater (1100 versus 1730 mg Γ min/mL) than that in control rats, a
## Abstract In rats pretreated with dexamethasone (an inducer of CYP3A1/2 in rats) and troleandomycin (an inhibitor of CYP3A1/2 in rats), the area under the plasma concentrationβtime curve from time zero to time infinity (__AUC__) values of clarithromycin were significantly smaller (365 compared wi