𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Influence of glycemic control on tympanic membrane healing in diabetic rats

✍ Scribed by Holger Kaftan; Lars Reuther; Bärbel Miehe; Werner Hosemann; Ingrid Klöting

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
267 KB
Volume
121
Category
Article
ISSN
0023-852X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objectives/Hypothesis:

It is generally assumed that glycemic control in diabetic patients is important in optimizing wound healing. The goal of this study was to examine tympanic membrane (TM) wound healing in spontaneously diabetic rats depending on the diabetic metabolic state compared to nondiabetic control animals.

Study Design:

Prospective controlled study in experimental animals.

Methods:

Right‐sided myringotomy was performed in 20 normoglycemic rats, 17 well‐compensated, and 23 poorly compensated diabetic rats. TMs were observed for a total of 3 weeks. Effect of diabetic metabolic state on the healing of the TMs was evaluated by closure rates and histology.

Results:

Diabetic rats showed a significant delay in TM wound healing compared to the control group, but there were no significant differences between both diabetes groups.

Conclusions:

Glycemic control does not influence TM wound repair in an animal model of type 1 diabetes. Laryngoscope, 2011

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