Retinoids are known to modulate sebaceous gland activity in humans and animals. The nonpolar arotinoid Ro 15-0778 [(E)-1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl-2-phenylethen yl) naphthalene] does not contain a polar end group and is devoid of the classical retinoid side effects of hypervit
โฆ LIBER โฆ
Influence of Food on the Bioavailability of Ro 15-0778 in Humans
โ Scribed by Alice A. Holazo; Evelyn E. Pinili; Francis T. De Grazia; Indravadan H. Patel
- Book ID
- 110341651
- Publisher
- Springer US
- Year
- 1990
- Tongue
- English
- Weight
- 442 KB
- Volume
- 07
- Category
- Article
- ISSN
- 0724-8741
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l, 4, )-alpha-methylstyryl]-naphtalene (Ro 15-0778), a potent inhibitor of sebaceous gland activity in several animal models has been administered to male volunteers in dosages of 1, 2, 3, and 6 mg]kg/day and 2 g[day for 8 weeks. Sebum production was measured before treatment and after 4 and 8 wee
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