𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Influence of farnesol on the morphogenesis of Aspergillus niger

✍ Scribed by Justine Lorek; Stefanie Pöggeler; Mirko R. Weide; Roland Breves; Dirk P. Bockmühl

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
433 KB
Volume
48
Category
Article
ISSN
0233-111X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Farnesol was the first quorum‐sensing regulator to be found in eukaryotic cells. In Candida albicans, a dimorphic fungal human pathogen, farnesol blocks the yeast‐to‐filamentous growth transition. Here we show that in Aspergillus niger farnesol acts as an inhibitor of conidiation: Colonies grown on media containing farnesol were unable to develop conidia. Although farnesol treated A. niger cultures exhibited a colony morphology resembling the “fluffy” phenotype of A. nidulans, which is caused by a hyperactive G‐protein/cAMP pathway, the intracellular level of cAMP in A. niger mycelia grown in presence of farnesol is greatly diminished. Furthermore, whereas inhibiting adenylyl cyclase led to a farnesol‐like effect, the addition of external cAMP inhibited conidiation without causing a “fluffy” phenotype. This suggests that the mechanisms regulating conidiation in A. niger and A. nidulans are different. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

📜 SIMILAR VOLUMES

Influence of acid phosphatase activity o
Influence of acid phosphatase activity on the saccharification of potato maltodextrins by aspergillus niger glucoamylase
✍ K. Żyła 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 295 KB 👁 2 views

A preparation of Aspergillus niger acid phosphatase, which had the temperature optimum 60°C, p H optimum 1.8-3.0; good stability a t p H 4-5, the ability to hydrolyze glucose-6-phosphate at a high rate, and substantial lack of glucogenic activities, was used simultaneously with a glucoamylase in ord

Kinetic studies on the aggregation of As
Kinetic studies on the aggregation of Aspergillus niger conidia
✍ L.H. Grimm; S. Kelly; J. Hengstler; A. Göbel; R. Krull; D.C. Hempel 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB 👁 2 views

Morphology has a crucial effect on productivity and the supply of substrate for cultures of filamentous fungi. However, cultivation parameters leading to the desired morphology are often chosen empirically as the mechanisms governing the processes involved are usually unknown. For coagulating microo