Influence of estrogen on intermediary metabolism in a teleost,Anabas testudineus and the lizardCalotes versicolor
✍ Scribed by Kaippallil, Jose D. ;Oommen, Oommen V.
- Book ID
- 102893154
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 655 KB
- Volume
- 270
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
Abstract
Administration of different doses of estrogen (5, 10, and 25 μg) in Anabas testudineus and Calotes versicolor inhibited the activities of alanine aminotransferase and aspartate aminotransferase. In Calotes, higher doses of estrogen (10 and 25 μg) increased the activity of glutamate dehydrogenase and in Anabas it was stimulated by all three doses. The total protein and RNA were also increased by all three doses of hormone in Anabas and Calotes. Higher doses of estrogen stimulated total DNA in Anabas and Calotes and the lowest dose (5 μg) did not have any significant effect. Activities of transaminases and glutamate dehydrogenase were inhibited and the protein content decreased by the administration of actinomycin and puromycin or simultaneous administration of estrogen and protein synthesis inhibitors. Actinomycin and puromycin alone did not have any significant effect on total DNA in Anabas and Calotes. Actinomycin reduced the level of RNA and puromycin did not produce any significant effect in Calotes. In Anabas actinomycin as well as puromycin decreased total RNA content. Simultaneous administration of estrogen and these inhibitors prevented the hormone mediated increase in the level of RNA and DNA both in Anabas and Calotes. © Wiley‐Liss, Inc.