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Influence of enhancers on the absorption and on the pharmacokinetics of cefodizime using in-vitro and in-vivo models

✍ Scribed by Yahya Mrestani; Beate Bretschneider; Reinhard H. H. Neubert; Albert Härtl; Matthias Brandsch


Book ID
111769102
Publisher
Pharmaceutical Press
Year
2004
Tongue
English
Weight
328 KB
Volume
56
Category
Article
ISSN
2042-7158

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The lipophilicity of propranolol is increased by some bile salts which form ionpairs. In the presence of taurodeoxycholate, the logarithm of the apparent partition coefficient (log P) of propranolol is increased. Moreover, the apparent diffusion constants in vitro of propranolol as ion-pairs at pH 3