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Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation

✍ Scribed by Alberto Sánchez-Fueyo; Christoph M. Domenig; Christophe Mariat; Sophoclis Alexopoulos; Xin X. Zheng; Terry B. Strom

Book ID
110916836
Publisher
Springer
Year
2007
Tongue
English
Weight
684 KB
Volume
20
Category
Article
ISSN
0934-0874

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Distinct roles of CTLA-4 and TGF-β in CD
Distinct roles of CTLA-4 and TGF-β in CD4+CD25+ regulatory T cell function
✍ Qizhi Tang; Elisa K. Boden; Kammi J. Henriksen; Helene Bour-Jordan; Mingying Bi; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB

## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut