Influence of dietary fiber on establishment and progression of atherosclerosis in rabbits

✍ Scribed by David Kritchevsky; Shirley A. Tepper

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 399 KB
• Volume: 6
• Category: Article
• ISSN: 0955-2863
• DOI: 10.1016/0955-2863(95)00104-8

✦ Synopsis

Rabbits were fed a .semtpur$ed diet containing 0.5% choksterol and either 14% cellulose or a psyllium-rich cereal (PRC) which actually prol,rded 6.27~ Jiber ~insolublefiber/solublefiber:2.21:1

.OO). The PRC-containing diet led to .signifcant!\ Iou'er serum total cholesterol. hrgher hrgh-densi lipoprotein (HDL) cholesterol. and less severe atherosclerosis. In a regression study. after 2 months on the atherogenic diet rabbits were placed on cholesterol-free diets c,ontarning 67~ corn oil and 147~ cellulose or PRC. After 3 months serum cholesterol levels had fallen bx 337~ in the group fed cellulose and b!, 51% it7 the group given PRC. Liver cholesterol levels fell by 62 and 744 m the cellulose and PRC groups. respectively. The average selserifi of atherosclerosis had risen by 35% in the cellulose group and bx on!\ 47c in the rabbits.frd PRC. This study shows that compared with 1470 cellulose, 6.27~ ps~llium,ft~d as part of an atherogenrc. dret resulted in lower serum and liver lipids and less severe atherosclerosi.s. (