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Influence of clonidine on the acute dependence response elicited in naive rats by naloxone

โœ Scribed by Richard M. Eisenberg

Book ID
118942368
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
283 KB
Volume
32
Category
Article
ISSN
0024-3205

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Naloxone HCl (10 micrograms/0.5 ml) was injected in the locus coeruleus (LC) of morphine-dependent rats and the behavioural manifestations of morphine withdrawal and the cortical levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) were measured 30 min later. Naloxone precipitated a