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Influence of cholesterol and lovastatin on α-form of secreted amyloid precursor protein and expression of α7 nicotinic receptor on astrocytes

✍ Scribed by Jin Xiu; Agneta Nordberg; Xiaolan Qi; Zhi-Zhong Guan

Book ID
116764848
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
371 KB
Volume
49
Category
Article
ISSN
0197-0186

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Lovastatin stimulates up-regulation of α
Lovastatin stimulates up-regulation of α7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the α-form of secreted amyloid precursor protein
✍ Jin Xiu; Agneta Nordberg; Ke-Ren Shan; Wen-Feng Yu; Jerker M. Olsson; Tomas Nord 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 455 KB

The cholesterol-lowering drug lovastatin enhances the secretion of the a-secretase cleavage product of amyloid precursor protein (APP). To investigate whether this effect is mediated via activation of a7 nicotinic acetylcholine receptors (nAChRs), we treated SH-SY5Y cells and PC12 cells with lovasta