Influence of cholestasis on drug elimination: Pharmacokinetics
β Scribed by Lester I. Harrison; Milo Gibaldi
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 270 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3549
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## Abstract The pharmacokinetics of lithium carbonate have been studied in 12 normal young volunteers when given alone and in combination with lornoxicam, a novel nonβsteroidal antiβinflammatory drug. Peak and 12βh lithium concentrations were significantly higher when both drugs were given together
The equation for the calculation of mean residence time of drug in plasma, t(p), is obtained. It is shown that the previously suggested calculation of t(p) considerably overestimates the true value in most cases. It is suggested that due to the possible initial (before establishing the uniform drug