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Influence of chiral uncharged Co(III) complexes on the helix–coil transition of poly-L-lysine

✍ Scribed by M. Barteri; M. Branca; B. Pispisa

Publisher
Wiley (John Wiley & Sons)
Year
1974
Tongue
English
Weight
418 KB
Volume
13
Category
Article
ISSN
0006-3525

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✦ Synopsis

Despite the large number of studies on the interaction between small molecules and macromolecules in solution, in few instances have bound molecules or ions been shown to affect the conformation of the polymeric substrate.1-6

We have recently found, during a study on the behavior of some cobalt and iron compounds in dissymmetric polyelectrolyte ~olutions,~.' that addition of as( -)$89tris(L-alaninato)Co(III) complex into charged poly-L-lysine (PLL) solutions gives rise to a marked increase of the a-helix structure of the polypeptide, provided a mixed solvent is employed (SOYo isopropanol-water mixture, by On the basis of experimental findings a3 well a i of stereochemical considerations we concluded that this effect was due to a specific site binding, arising from the structural features of the octahedral compound suitable for a multibonding interaction with the macroion, where intermolecular hydrogen bonds play a significant role.8 This conclusion is now also supported by quantitative data obtained with binding experiments and by a new set of optical results.

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