Influence of cell density and receptor number on the binding and distribution of cell surface epidermal growth factor receptors
β Scribed by Charles A. Kuszynski; Keith A. Miller; Angie Rizzino
- Book ID
- 112801893
- Publisher
- Society for In Vitro Biology
- Year
- 1993
- Tongue
- English
- Weight
- 670 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1475-2689
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Previously, it has been shown that the binding of epidermal growth factor (EGF) by a wide range of cells decreases as cell density increases. In this report, we demonstrate that KB cells treated chronically with phorbol esters continue to exhibit decreases in EGF receptor binding as cell density inc
## Abstract Epidermal growth factor (EGF) at nanomolar concentrations stimulated DNA synthesis in confluent, serumβstarved cultures of calf aorta and human uterine smooth muscle cells. Stimulation of DNA synthesis in lens epithelial cells was studied for comparison. L and Dβascorbic acid potentiate