Influence of CD4+ lymphocyte counts on GB Virus C/Hepatitis G Virus Carriership In HIV-Positive Individuals

✍ Scribed by Goubau, Patrick; Liu, Hsin-Fu; Goderniaux, Emmanuelle; Burtonboy, Guy

• Book ID: 101216928
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 59 KB
• Volume: 57
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/(sici)1096-9071(199904)57:4<367::aid-jmv7>3.0.co;2-3

✦ Synopsis

The duration of the GB virus C or hepatitis G virus (GBV-C/HGV) carriership varies according to the patient group studied. The immune competence of the host may be important. GBV-C/ HGV was studied in human immunodeficiency virus (HIV)-infected persons and an attempt was made to correlate the presence of viral RNA or E2 antibodies with CD4 + lymphocyte counts. Of 138 HIV-positive subjects, 30 were GBV-C/HGV RNA-positive and 20 others were E2 antibodypositive, whereas in healthy GBV-C/HGV-infected persons, the proportion of E2 antibody carriers was much higher. On the other hand, a relationship was not found between CD4 + lymphocyte counts and the presence of GBV-C/HGV RNA in the HIV-infected persons. This result does not necessarily imply that the CD4 + lymphocyte count does not affect viral clearance, but the results could be due to the transsectional nature of this study. A longitudinal assessment should clarify this point.