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Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG

✍ Scribed by D Groenendaal; J Freijer; D de Mik; M R Bouw; M Danhof; E C M de Lange

Book ID
110009534
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
260 KB
Volume
151
Category
Article
ISSN
0007-1188

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✍ Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,