The distribution and elimination kinetics of griseofulvin have been examined in man. T h e drug was administered intravenously in polyethylene glycol 300 via a saline drip. The plasma-concentration time cuwe was satisfactorily described by a bi-exponential equation, the half-life for the first expon
Influence of bile salts and lipids on intestinal absorption of griseofulvin in man
โ Scribed by R. Palma; N. Vidon; G. Houin; A. Pfeiffer; M. Rongier; J. Barre; J. J. Bernier
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 896 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
## RISEOFULVIN is given in large amounts and is Its dose in man is 12.5-500 mg., and its water solubility is 15 mcg./ml. at 37'. If the digestive fluids are saturated with respect to griseofulvin at all times, and griseo-
The lipophilicity of propranolol is increased by some bile salts which form ionpairs. In the presence of taurodeoxycholate, the logarithm of the apparent partition coefficient (log P) of propranolol is increased. Moreover, the apparent diffusion constants in vitro of propranolol as ion-pairs at pH 3