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Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells

✍ Scribed by Allouche, Michèle; Bettaieb, Ali; Vindis, Cécile; Rousse, Aline; Grignon, Cécile; Laurent, Guy

Book ID
110060644
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
500 KB
Volume
14
Category
Article
ISSN
0950-9232

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We have previously shown that in myeloid leukemic cells, daunorubicin (DNR) induces apoptosis via the activation of the sphingomyelin-ceramide pathway. We have now investigated sphingomyelin (SM) hydrolysis, ceramide generation, and apoptosis in vincristine-selected multidrug resistant (MDR) HL-60 c