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Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts

✍ Scribed by Charles D. Wolleben; Michael C. Sanguinetti; Peter K.S. Siegl

Book ID
118916758
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
723 KB
Volume
21
Category
Article
ISSN
0022-2828

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Modulation of ATP-sensitive potassium ch
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✍ C. G. Nichols; E. Niggli; W. J. Lederer πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 355 KB

We have used 'caged-ATP' to investigate the kinetic behavior of KATP channels in ventricular cells from rat heart. In whole cells, loaded with 'caged-ATP', an increase of intracellular [ATP] following a UV light flash produced a decrease of KATP channel current that was too slow (tau approximately 3