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Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients

✍ Scribed by Suman Lal; Zee Wan Wong; Edwin Sandanaraj; Xiaoqiang Xiang; Peter Cher Siang Ang; Edmund J. D. Lee; Balram Chowbay


Book ID
108584138
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
218 KB
Volume
99
Category
Article
ISSN
1347-9032

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## Abstract ## BACKGROUND. The authors investigated whether __ABCB1, ABCC2,__ and __ABCG2__ genetic polymorphisms affect pharmacokinetics (PK) of irinotecan and treatment outcome of patients with advanced nonsmall cell lung cancer (NSCLC). ## METHODS. Blood samples from 107 NSCLC patients treate