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Influence of 50-Hz magnetic fields and ionizing radiation on c-jun and c-fos oncoproteins

✍ Scribed by I. Lagroye; J. L. Poncy

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
100 KB
Volume
19
Category
Article
ISSN
0197-8462

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✦ Synopsis

The effect of magnetic fields (50 Hz, 100 microT[rms] sinusoidal magnetic field combined with a 55 microT geomagnetic-like field) and/or gamma rays of 60 Cobalt on the expression of the c-jun and c-fos proteins was investigated in primary rat tracheal epithelial cells and two related immortalized cell lines. Quite similar patterns and amplitudes of induction of these proteins were evidenced after either ionizing radiation or magnetic field exposure. No synergism after both treatments was observed. These findings suggest that magnetic fields explored in the present study may be considered as an insult at the cellular level.

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## Abstract **BACKGROUND:** We exposed pregnant mice to magnetic or sham fields for 24 hr/day during Gestation Day (GD) 5.5–8.5 to study the effects of 50‐Hz 0.1‐mT sinusoidal magnetic fields on early pregnancy in mouse embryos and mice. **METHODS:** Mice were sacrificed on GD 8.5. Embryos and bloo