Large unilamellar dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG) liposomes loaded with an aqueous chemotherapeutic drug, cytosine arabinofuranoside (ARA-C), were exposed for 30 min to 60 W/kg continuous-wave (CW) 100-MHz or 2.45-GHz radiation in vitro at temperature
Influence of 2.45-GHz CW microwave radiation on spontaneously beating rat atria
✍ Scribed by M. J. Galvin; M. S. Dutton; D. I. McRee
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 415 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0197-8462
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✦ Synopsis
Abstract
The chronotropic and inotropic effects of 2.45‐GHz continuous wave (CW) microwave radiation were investigated in the isolated spontaneously beating rat atria. Isolated atria were placed in specially designed tubes inserted into a waveguide exposure system. The atria were then irradiated for a period of 30 min, followed by a 30‐min recovery period. The control atria were prepared simultaneously and sham exposed. Experiments were conducted at two temperatures, 22 and 37 °C, and two specific absorption rates, 2 mW/g and 10 mW/g. At both temperatures the rate of atrial contraction was not altered by a 30‐min exposure at either 2 or 10 mW/g. The average rate (beats per min) was approximately 100 for both the control and exposed atria at 22 °C and 215 beats per min for both the control and exposed atria at 37 °C. In addition, no inotropic effects on the spontaneously beating atria were noted at any exposure level. These data suggest that 2.45‐GHz CW microwave radiation at these intensities has no overt effect on these variables in isolated rat atria.
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