## Abstract Proliferation and differentiation of osteoclasts are regulated by a cytokine system that includes RANKL, which binds 2 receptors: RANK, which activates osteoclast differentiation, and osteoprotegerin (OPG), a decoy receptor that limits RANKL action. We investigated the role of the OPG/R
✦ LIBER ✦
Infliximab acts directly on human osteoclast precursors and enhances osteoclast formation induced by receptor activator of nuclear factor κB ligand in vitro
✍ Scribed by Chikahiro Takita; Yosuke Fujikawa; Ichiro Itonaga; Hirofumi Taira; Masayuki Kawashima; Takehiko Torisu
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 372 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1439-7595
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## Abstract CXCL8 is a CXC chemokine that recruits leukocytes to sites of inflammation. Expression of CXCL8 in the CNS has been demonstrated in neuroinflammatory diseases, including human immunodeficiency virus (HIV‐1) encephalitis, but the mechanism of secretion of this chemokine is not fully unde