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Inflammatory Mediators May Have Divergent Roles in Cancer and in Alzheimer's Disease

โœ Scribed by Metz, R A; Balin, B J; Abrams, J T; Schrogie, J J

Book ID
109846070
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
62 KB
Volume
88
Category
Article
ISSN
0009-9236

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## Abstract Hypoxiaโ€inducible factor (HIF)โ€1 and HIFโ€2 are heterodimeric transcription factors that mediate the cellular response to hypoxia. Their key regulatory subunits, HIFโ€1ฮฑ and HIFโ€2ฮฑ, are induced similarly by hypoxia, but their functional roles in cancer may be distinct and isoformโ€specific