Inflammatory Disorders

✍ Scribed by Mieczyslaw Pokorski (eds.)

• Publisher: Springer International Publishing
• Year: 2015
• Tongue: English
• Leaves: 74
• Series: Advances in Experimental Medicine and Biology 839
• Edition: 1
• Category: Library

✦ Synopsis

The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.

✦ Table of Contents

Front Matter....Pages i-x
Inhaled Corticosteroids Increase Siglec-5/14 Expression in Sputum Cells of COPD Patients....Pages 1-5
Tregs and HLA-DR Expression in Sputum Cells of COPD Patients Treated with Tiotropium and Formoterol....Pages 7-12
Inhalation of Macrolides: A Novel Approach to Treatment of Pulmonary Infections....Pages 13-24
Influence of Denture Plaque Biofilm on Oral Mucosal Membrane in Patients with Chronic Obstructive Pulmonary Disease....Pages 25-30
Biophysical Activity of Animal-Derived Exogenous Surfactants Mixed with Rifampicin....Pages 31-39
Organic Changes in the Central Nervous System in Children on Chronic Inhaled Corticosteroid Therapy....Pages 41-45
Stem Cell Experiments Moves into Clinic: New Hope for Children with Bronchopulmonary Dysplasia....Pages 47-53
Soluble Ligand CD40 and Uric Acid as Markers of Atheromatosis in Patients with Obstructive Sleep Apnea....Pages 55-60
Carotid Artery Intima-Media Thickness in Hypertensive Patients with Obstructive Sleep Apnea....Pages 61-66
Back Matter....Pages 67-67

✦ Subjects

Pharmacology/Toxicology; General Practice / Family Medicine; Health Promotion and Disease Prevention; Pneumology/Respiratory System